The first and second familiars spawn after 15 hits, then 30 hits for the third and fourth, Cambion Conception cannot grant more than 4 familiars in total, UNLOCK: Unlock this item by beating ??? PC 9SS3 3YXY (Second floor treasure room) (+ Technology 2 on third floor), PC GXSE V7P4 (Treasure Room adjacent to spawn), PC EZTZ CL68 (Treasure Room adjacent to spawn), PC RR0G KKQJ (Treasure Room adjacent to spawn), PC 6FDS 6FWF (Treasure Room adjacent to spawn), PC PCM8 R3H4 (Treasure Room adjacent to spawn), PS4 GXA1 L6XC (Treasure Room adjacent to spawn), PS4 27T2 26G0 (First floor Treasure Room), 3DS 11DA E0JZ (Treasure Room adjacent to spawn), Switch AL2T Q6NC (First Golden Treasure Room), Achievements Each tick of poison damage is equal to your normal tear damage, Some random tears will gain the Rubber Cement effect and become bouncy, Grants +0.25 Speed, +0.75 Range, +0.1 Shot Speed, +0.2 Tears, +0.5 Damage and +1 Luck when Isaac's active item is fully charged, Infinite use items such as Potato Peeler count as charged and provide the bonus from this trinket, Grants +0.5 Speed, +1.5 Range, +0.3 Shot Speed, +0.4 Tears, +1.5 Damage when Isaac's active item is completely uncharged, One-time use items such as Mama Mega count as uncharged and provide the bonus from this trinket, Gives you another secret room on each new floor while held, Does not spawn more than one super secret room, only the normal secret room, *, purple, torn, ripped, paper, page, poster, When you have the same amount of coins, bombs and keys, half consumables turn into their doubled version, This effect works for any number of consumables, including 0 and 99, as long as the count for coins/keys/bombs is equal, Every time you take damage you have a very small chance to spawn a random pedestal item, When the effect triggers, the trinket is destroyed, Every time you take damage you have a very small chance to spawn the Lunch item, which gives +1 HP up, When the effect triggers, this trinket is destroyed, Increases the radius of any creep you produce, While held, any damage taken remove red hearts first, before soul hearts, black hearts and rotten heart damage, While at 1/2 of a red heart, it will begin to remove your other hearts again, UNLOCK: Unlock this item by beating Greedier mode with Eve, The Walnut has a chance to break when taking damage from an explosion. Touching the white flame temporarily turns you into The Lost, but allows you to walk through the mirror into a mirrored version of this floor. Unlocked from the 'Dedication' achievement (participate in 31 dailies in a row), I'm Drowsy - Slows all enemies for the rest of the current room, I'm excited!!! poop, pots), Counts as 1 of 3 cat items needed towards the Guppy transformation, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Cain, Item Pool: Devil Room, Curse Room, Red Chest, Spawns a Keeper familiar, that shoots triple tears and follows your exact movements as you walk, The keeper has 3 health coins and can die if it takes enough damage. White poop Dips have a small Hallowed Ground aura effect, increasing your damage and fire rate while standing in it. Every 6 coins Bumbo will evolve to a new form except for level 4 which takes 12 coins, Level 2: Bumbo gains a body and crawls around the room, sometimes dropping random pickups, Level 3: It now fires tears in the same direction Isaac does, Level 4: Bumbo no longer fires tears but instead will chase enemies slowly and deal contact damage. Pickups *, bag, grey, cry, blue, tear, shia paper bag sackhead, sad, Gives Isaac a cone of light infront of him that slows any enemies inside it and their tears, The light faces the direction that you are facing, not the direction you are firing, Removes Curse of Darkness for the current floor, if picked up on a floor where the curse is active, * Shop, Greed Mode Item Room, white, blue, inhaler, A purple familiar fly that follows your exact movement on a 1 second delay and deals 2 contact damage to enemies, When used, places an explosive TNT barrel next to you, The TNT barrel can be pushed and used to explode rocks or damage enemies, If used a second time in the same room while the last TNT barrel is still there, it will remotely explode the first TNT and not spawn another, REPENTANCE - Added to the Gold Chest Pool. The Knife Piece 1 is located in the Item Room in the mirrored area. It stops moving while Isaac is firing tears and upon releasing the fire button, King Baby will teleport back to your location, King Baby will always appear first in the queue of familiars, REPENTANCE - Familiars now automatically aim at enemies when being commanded by King Baby. If you didn't find one before this point, there will be a tinted Skull somewhere on Depths II, which contains a Fool card when blown up. Manage all your favorite fandoms in one place! Each poop has random effects like Butt Bombs, Fire Poops etc, Tainted Blue Baby starts with this item, and is the only one who can use it, Spawns 3 random coins and a key when picked up, Buying items from the shop gives you random stat upgrades. Items Lil Clot is an unlockable trinket added in The Binding of Isaac: Repentance. The spear occasionally inflicts fear on enemies it damages. Fires 3-5 additional beams in random directions around Isaac. Cain no puede disparar lgrimas . The angel room spawned by The Stairway item also counts, Giving money to a beggar gives a flame orbital, UNLOCK: Unlock this trinket by defeating Mother as Tainted Bethany, Upon entering each new room, this trinket has a chance to copy one of your current familiars, If you have no familiars instead it will spawn either Brother Bobby or Sister Maggy, UNLOCK: Unlock this trinket by defeating Isaac, ?? Challenges After killing a 25 more enemies, it transforms again dealing 15 damage and destroying obstacles it charges into. spikes, creep). Spawns another Vurp! The new rooms contain 0-3 Devil Deal Items, 1-3 Black Hearts and random enemies from the Sheol floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Judas, Opens the door to the Blue Womb, regardless of whether you meet the 30 minute speed timer, Opening Pandora's Box while holding this item will ignore the normal effect and instead spawn 6 item pedestals from random item pools. Rooms Red chests), Can be used in a shop to duplicate pickups which have not yet been purchased, and take the duplicate pickup for free, UNLOCK: Unlock this item by defeating Greedier Mode with Isaac, When used, Void will consume any pedestal items in the current room, If an active item is consumed, its effect will be added to Void's effect when used, allowing you to consume multiple items and combine their effects, If a passive item is consumed, you gain a small stat upgrade to a random stat, Possible stat changes include: +1.0 flat damage, +0.5 tears, +0.2 speed, +0.2 shot speed, +0.5 range, +1.0 luck, Void does not work on devil deal or shop items unless they have been bought first, Using Void to absorb items in Boss Rush or Challenge Rooms counts as taking the items and will cause the encounter to start, Using Void on one time use items such as Mama Mega or Diplopia will cause their effect to instantly trigger and will not give you further uses through activating Void again, UNLOCK: Unlock this item by beating Delirium in The Void floor with Apollyon, Upon use, this item freezes all enemies in the room until you press the fire button again or 30 seconds passes (whichever happens first), Unlike other active items, bosses are not immune to this effect, Touching a frozen enemy will still hurt you, This item doesn not affect troll bombs - they will still explode, Upon use, the Smelter will destroy your currently held trinket and give you the effect permanently, allowing you to stack up lots of different trinket effects, Holding the Smelter increases the chance for a trinket to drop. - Gives the curse of the maze effect for the current floor. +5 range. Pressing the bomb button will put the next poop into the 'Hold' jar. He won't respawn even if you move to a new floor, Will always match your current movement speed, UNLOCK: Unlock this item by defeating The Beast as Tainted Keeper, Only found in the Mausoleum/Gehenna II boss room, The item itself has no effect, but triggers the ascent through the backwards path towards the Home floor. Increasing tears stat will increase damage and width brimstone as well. bomb beggar, green, dead, face, bobs curse, bob curse, Spawns 7 random coins around Isaac on the floor, * boss room pool, boss room item, dtQt, dtphase, crown, nocrown, yescrown, diana, ?, Satan and The Lamb as Tainted Eve, A small clot friend will hug Isaac, following his exact movements (similar to how Jacob & Esau work) and shooting tears when he does, The clot can be moved around by collision with an object/wall, allowing you to re-position it, The clot's damage is roughly 1/3 of your tear damage, If it takes a few hits it will die, and respawn in the next room, UNLOCK: Unlock this trinket by defeating Mother as Tainted Eve, Spawns a random chest after completing a regular Challenge Room, Spawns a pedestal item after completing a boss Challenge Room, UNLOCK: Unlock this trinket by defeating Isaac, ?? This familiar moves and shoots through the same inputs as Isaac, effectively acting as a second source of tears. Binding of Isaac: Rebirth Item guide series===Support me===Monthly on Patreon: https://www.patreon.com/syncerOne-time donation: https://www.paypal.com/cgi-bi. However after the first damage tick, there is an additional pause for ~0.12 seconds (7 frames). Corpse II drops same as Womb II, UNLOCK: Unlock this item by beating the Dark Room with Lazarus, * red chest pool, red chest item pool, shop room pool, shop item pool, blue box, pandoras box, When used, turns Isaac invincible and gains +0.28 speed for a 5 seconds, You cannot fire tears while the stump is active, Very similar to the My Little Unicorn item but does not deal contact damage, When used with Mom's Knife, you can still deal contact damage but will be unable to change the way the knife faces while the effect is active, * item room, treasure room, item room pool, white, lump, grey, gray, blob, While in a hostile room your speed raises at a rate of +0.065 per game tick, When you hit a speed stat of 2.0, Isaac will gain an invincibility effect for 5 seconds, increasing speed and allowing him to run into enemies to deal 40 contact damage per hit, The time it takes for the effect to activate becomes shorter with a higher base Speed stat, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, circle, horns, Gives huge horns which stick out, allowing you to deal 18 contact damage if you hit something with enough speed, Will not deal contact damage unless you are moving fast enough (at least 0.8 speed), REPENTANCE - Aries now prevents receiving contact damage if ramming and killing enemies at full speed, * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan, glow, After getting hit once, you gain a damage reduction for the rest of the room similar to The Wafer item (-50% damage taken), * astrology, astronomy, item room, treasure room, item room pool, cyan, black, the lost item pool, This tear turns enemies to gold for a few seconds and causes them to drop 1-4 coins if killed while golden (similar to the Midas' Touch item), When the Midas Touch tear effect triggers, it will remove 1 coin from your current total, The golden tear deals double your tear damage, The effect can still trigger even if you have no held coins, UNLOCK: Unlock this item by defeating Greedier Mode with Keeper, Doubles the effect of most tarot cards. Seeds Counts as 1 of 3 book items needed towards the Bookworm transformation. It leaps at enemies, dealing contact damage and firing quad shots at them for the rest of the room. soul or black hearts, Your devil deal chance isn't ruined by this item taking away red hearts. His range is unaffected. Spoon Bender, Telepathy for Dummies, I - The Magician), While held, gives you a small chance to gain a bone heart everytime you take damage, REPENTANCE - Finger Bone's chance to grant a bone heart has been increased to 5% per hit taken (from 2%), UNLOCK: Unlock this trinket by defeating Ultra Greed as The Forgotten, Teleports the player to the first room of the current floor, There is a guaranteed Fool card in the Depths 2, if you bomb the skull with an X on it. Trinkets treasure room, item room pool, yellow, golden, ring, circle, Item Pool: Item Room, Shop, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, item room, treasure room, item room pool, yellow, red, blue, medicine, jar, drug, moms bottle of pills, Tears now have a random chance to apply a poison effect, causing double your tear damage per tick to enemies over time, The chance to fire poison shots is affected by your luck stat and at +12 Luck it will activate every time, * item room, treasure room, item room pool, green, snot, booger, ball, slime, Isaac's tears now split into two upon contact with enemies or the environment, Tears that split off from the main tear do less damage (tear damage * 0.5), Tears can keep splitting if they still have range and damage above 1, UNLOCK: Unlock this item by collecting two of the following items: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head, * item room, treasure room, item room pool, pink, slug, bug, face, When used, replaces all pedestal items in the current room with another random item. The scattered tears deal random damage that is 50-83.33% of the main tear. The scattered tears deal random damage that is 50-83.33% of the main tear. arrow, Causes your friendly blue spiders and flies to become bigger and do x2 more damage, Allows Mom's Wig to spawn a maximum of 10 spiders at once instead of 5, Fly and spider familiars become stronger similar to BFFS, * shop room pool, shop item pool, blue, fat, Two items now spawn after beating a boss fight and the boss rush, however only one can be taken, The additional item will pick from the Boss Item Pool, Unlocked by donating to the donation machine in the shop, UNLOCK: Unlock this item by donating 50 pennies to the Shop, * shop room pool, shop item pool, white, question mark, square, theres options, * shop room pool, shop item pool, purple, paper, ticket, Isaac can now hold 2 cards or runes at once. the lost item pool, gold, orange, yellow, cross, pope, hat, A familiar the follows Isaac and fires random tears, Rainbow Baby's tears can choose from any of the other familiars, such as homing, spectral, tar shots etc, * item room, treasure room, item room pool, purple, Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors, Can be used to open the golden door that appears in the Dark Room or the Chest, Cannot be used to escape the Mom's Foot boss, open angel/devil rooms, or open the door to the Blue Womb floor, UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, #1. red, bolt, cupid arrow, cupids arrow, When used, fires a high damage laser in a straight line across the room in a similar way to Brimstone, The laser deals damage equal to double your tear damage. shortness of breath. Jun 05, 2008 |. It will hunt down other enemies, dealing contact damage which scales with your tear damage, After 5 seconds the red soul explodes (Isaac doesn't take damage from this effect), UNLOCK: Unlock this item by defeating The Beast as The Lost, *, this item is irrelevant 99.94% of you wont kill the beast as the lost me included :(, When used, gives you number of blue flame orbitals based on the number shown over this item, It starts at 1, and increments each activation, giving you more familiars each time you use it, The flames fire tears at the same time Isaac does, that deal a flat 3 damage, If a flame touches an enemy, it deals contact damage equal to double your current tear damage and then disappears, You can have a maximum of 24 flame orbitals at once, Each flame has a chance to spawn as one of many variants, such as green flames that poison enemies, or a crucifix flame that spawns a random horseman familiar + Locusts when it is extinguished, UNLOCK: Unlock this item by defeating The Beast as Bethany, Soul hearts give you small permanent stat increases when picked up, Possible stats include +0.3 Range Up, +0.2 Luck Up, +0.2 Damage Up, +0.1 Tears Up, +0.04 Speed Up, UNLOCK: Unlock this item by defeating Greed Mode as Bethany, Spawns a random charmed enemy which fights by your side and copies your exact movements, similar to how Jacob & Esau work, The familiars fire tears at the same time as Isaac, and have a visible health bar showing how much damage they can take before dying, UNLOCK: Unlock this item by defeating The Beast as Jacob & Esau, You respawn as a tiny version of Isaac, with a greatly reduced hitbox and +0.2 Speed Up, When the effect activates you deal 35 damage to nearby enemies, Once unlocked, if you have already unlocked the tainted version of the character you're playing as, Inner Child is guaranteed to spawn in the hidden closet on the Home floor, UNLOCK: Unlock this item by defeating Greed Mode as Jacob & Esau, Item pedestals now cycle between 5 random items, UNLOCK: Unlock this item by defeating The Beast as Tainted Isaac, Enemies that touch Isaac will now bounce off him and fly off in the opposite direction, Bounced enemies will take 10 damage if they slam into the wall, This item also gives a random chance for enemy shots to bounce off you without taking damage, UNLOCK: Unlock this item by defeating The Beast as Tainted Magdalene, 33% chance to reroll items with a quality of 2, Quality is a hidden mechanic in Repetance for all items and ranges from 0-4. When the effect wears off, Isaac quickly runs between each marked enemy, dealing high damage to each one rapidly (roughly x2.5 your tear damage), The damage caused by this effect scales up with every target it hits in a row, UNLOCK: Unlock this item by defeating Delirium as Tainted Judas, *, budas, jubas, sword, blood, omae wa mou shindeiru, When used, Abyss consumes all pedestal items in the current room and converts them into Red attack flies, Red attack flies will charge across the room in the same direction Isaac is shooting, dealing contact damage to enemies equal to Isaac's tear damage, The flies don't block enemy shots, but this also means they never die and stay with Isaac forever, UNLOCK: Unlock this item by defeating Delirium as Tainted Apollyon, Staples one of Isaac's eyes shut, meaning he only shoots tears from one eye. A fully charged laser deals 31.5 damage. The stationary head is now affected by Isaac's stats and attack modifiers, and the body will spew a controllable fountain of blood shots. Bosses Taking it will cause Mom's Shadow to spawn and chase you. Doesn't apply to progress items like The Polaroid, When you pick up an item that increases your maximum HP, you gain 2 permanent stat increases, and a temporary damage boost that slowly goes down over time. Killing a petrified enemy will freeze it. Curses Duplicating Lil Clot trinkets will cause them to stack, allowing Isaac to control multiple Lil Clots at once. +2 flat damage to tears fired from Isaac's left eye. starting, blue, white, glow, cross, You can now break obstacles by walking over them, Holes in the ground can be filled by crushing adjacent rocks, similar to how this can be done with bombs, * item room, treasure room, item room pool, cheetos, cheese, grey, gray, orange, jar, Enemies and pickups (keys, bombs etc.) . You still take damage however when using Blood Donation machines and Devil Beggars, *, spikes, spikey, spike rock, greyhost, grey host, Causes all pedestal items to show up as rotating items, that swap every 1 second between the original spawned item and a HP up item. Epic Fetus . the lost item pool, purple, cross, Item Pool: Curse Room, Devil Room, Demon Beggar, * curse room pool, devil pool, devil room pool, devil deal, red, 666, Item Pool: Devil Room, Curse Room, Demon Beggar, * curse room pool, devil pool, devil room pool, devil deal, piece of paper, bloody paper, contract, Only stat effects are applied; otherwise overridden by Brimstone: PC 39W8 NGWZ (Red Chest on Curse Room adjacent to spawn) Effects Character Appearance Larry Jr.) it will split them into 2 smaller enemies with half the number of sections they used to have, If the enemy normally has a mechanic that splits it (e.g. Any Tarot card or rune on the floor or current held when picking this item up will change into a pill, Dice Shard counts as a card and will be converted, UNLOCK: Unlock this item by picking up 2 of the following items: Roid Rage, The Virus, Growth Hormones, Experimental Treatment or Speed Ball, * shop room pool, shop item pool, brown, purple, * boss room pool, boss room item, red, wedge, purple, triangle, The above stats only apply to tears fired from Isaac's left eye or with a 50% chance if you have an item which causes you to fire from a single source only, * boss room pool, boss room item, red, blob, circle, spot, * boss room pool, boss room item, grey, gray, Enemies touching placed bombs take 16 damage, Gives all bombs a burning effect when they explode, leaving fire on the floor which deals 22 damage to enemies, REPENTANCE - Hot Bombs now have greatly increased contact damage (increased from 1 to 16), and passively grants Isaac immunity to fire, * item room, treasure room, item room pool, fire, orange, flame, face, Isaac's tears now set enemies on fire, leaving a damage over time effect that does 4 or 6 damage per tick, There is a chance that tears that hit enemies will explode, leaving a small fire on the floor that damages enemies, Exploding tears deal damage * 2 + 22 per tick, The chance for tears to explode is affected by your luck stat and at +13 Luck it will activate every time, * item room, treasure room, item room pool, fire, flame, orange, back, ball, burning, When picked up, and at the start of each floor this rerolls all your current items, giving you a new item to replace each of the ones you had, Also rerolls all your stats at the same time, giving a random flat modifier that changes each time, Doesn't affect important items such as Polaroid, Negative and Key Pieces, UNLOCK: Unlock this item by beating Boss Rush with Lazarus, * secret room pool, mondrian, painting, yellow, blue, red, white, Tears now have a chance to apply the fear effect to enemies, which causes them to run away from Isaac, The chance to fear enemies is affected by your luck stat and at +20 Luck it will activate every time, An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool), * devil pool, devil room pool, devil deal, grey, gray, fist, glow, Immunity to all floor curses (e.g. Each tear has a random size multiplier between 0.9x to 1.33x, but there is no effect on damage. Taking a Devil deal breaks the cross and prevents the damage up next floor, Taking free pickups such as Black hearts in the Devil room also count, UNLOCK: Unlock this item by defeating The Beast as Judas, When you die, you turn into a ghost with 1/2 a red heart and flying, that is chained to your body for 10 seconds. Activating Sumptorium restores Tainted Eve's health (if possible) and axes living clots (though not all of them? This allows you to stay alive as long as you don't get hit during this 10 second period, After this effect occurs, it cannot activate again until Isaac gains a half or full Soul Heart or a Black Heart. (page 5, column 6, row 3)(page 5, column 7, row 3) First, chemical signals cause the injured vessels to narrow to prevent more blood from leaking out. Brimstone Blood laser barrage. After a minute or so of not hurting her she will fly away and spawn Plum Flute, UNLOCK: Unlock this item by allowing Baby Plum to escape instead of killing her, Spawns a star with a white aura around it, that floats very slowly through each room on the floor, making its way towards the boss room, While standing inside the aura, you gain a big Tears Up (x2.5 fire rate), Damage Up (damage * 1.2 + 1) and homing tears, The star continues to make its way through the floor, even if you aren't in the same room as it, moving faster if you are a long distance ahead of it, On The Void floor, it will move towards the boss room containing Delirium, Doesn't travel into the Hush or Mega Satan boss room, It may travel through secret/curse rooms on its route to the boss room, Counts as 1 of 3 astrology items needed in the same run to unlock Planetariums, UNLOCK: Unlock this item by defeating Delirium as Bethany, Gives you a baby in an ice cube, which can be kicked around the room by walking into it, Enemies take damage from Cube Baby depending on how fast it was travelling when it hit them. The first piece drops by beating the first floor boss within 1 minute then bombing the shadow in the first room. REPENTANCE - This item was completely reworked for Repentance and no longer forces a random dice use each time. Krampus Head) can still spawn, Bible drops caused by the Rosary item are not prevented by this trinket, *, stop, red, circle, line, cross, entry, warning, Causes your familiars to stay closer to each other, Poop in the environment will now explode when destroyed, While held you have an increased chance for Black Poops to spawn, which deal damage to all enemies in the room when destroyed, Gives The Poop active item a chance to spawn a Black Poop too. Brimstone's charge (open mouthed laser) will overlap any item that is on the player's face; this is obviously a graphical bug. pink, purple, Spawns a familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one, The Leech deals 1.5 contact damage per tick, * item room, treasure room, item room pool, grey, gray, worm, A bag that follows Isaac and drops a random heart, coin, bomb or key every 5-6 rooms (alternating, 5 rooms then 6, then repeats), Can drop any kind of heart, coin, bomb or key, UNLOCK: Unlock this item by beating the Dark Room with Eden, Item Pool: Item Room, Beggar, Secret Room, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, secret room pool, item room, treasure room, item room pool, mysterious sack, multiple sacks, bag, pouch, purple, question mark, A large familiar black fly that bounces around the room, exploding on contact with enemies dealing 70 damage, Does not explode if it hits Isaac, however if it explodes on an enemy while Isaac is in range, he will take damage, Respawns after 10 seconds or by moving to another room, * item room, treasure room, item room pool, heart, smile, A green brain that launches in the direction you are firing your tears and will explode on contact with enemies, dealing damage and poisoning anything in the blast radius, Bob's Brain deals 100 damage and applies a poison damage over time effect, which deals double your tear damage per tick, Will hurt Isaac if he is in the blast radius. Broken hearts permanently subtract from your total possible health containers, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Magdalene, Isaac turns to stone and can't move for 10 seconds, but your tear rate goes up significantly for the duration, UNLOCK: Unlock this card by defeating challenge #42 (Hot Potato), UNLOCK: Unlock this card by defeating challenge #43 (Cantripped), "May you see the value of all things in life", When used, all items and pickups in the current room are turned into money. Interactions. Objects UNLOCK: Unlock this card by beating Challenge #12 (When Life Gives You Lemons), When used, will open all doors in the current room, similar to a one-time use of Dad's Key, UNLOCK: Unlock this card by beating Challenge #22 (Speed), When used this card will activate a use of your spacebar item for free, When used, this rune will destroy all breakable objects in the current room, such as poop, rocks, secret room entrances, UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black), When used this rune will double all pickups on the floor in the room, Creates copies of pickups in the Shop which can be taken for free, even if you haven't purchased them yet, Can be used to double the number of item chests in the first room of the final Chest / Dark Room floors, Cloned chests have the same types of items as the first one, Cannot be used to clone trinkets or other Jera runes, UNLOCK: Unlock this card by beating Challenge #2 (High Brow), UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma), Removes the curse which is in effect on the current floor (except Curse of the Labyrinth), Can also cure the effect of the Amnesia pill, UNLOCK: Unlock this card by beating Challenge #4 (Darkness Falls), When used, reveals the entire map including all the secret room locations and other icon rooms, UNLOCK: Unlock this card by beating Challenge #5 (The Tank), Rerolls all pedestal items in the current room (One time use of the D6), UNLOCK: Unlock this card by beating Challenge #6 (Solar System), Summons 3 blue friendly spiders and 3 blue flies, UNLOCK: Unlock this card by beating Challenge #20 (Purist), When used, gives you an invincibility effect which lasts for 20 seconds, UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue), When used, gives a random Mystic rune effect, Possible effects include: Algiz, Ansuz, Berkano, Dagaz, Ehwaz, Hagalaz, Jera, Perthro, Also has a 25% chance to spawn another Blank Rune upon use, UNLOCK: Unlock this card by beating Challenge #30 (Guardian), When used, this rune deals 40 damage to all enemies in the room and consumes all pedestal items in the room, giving you a random stat increase for each item consumed, Also consumes all pickups in the room and turns them into blue flies and spiders, UNLOCK: Unlock this item by beating Greedier mode as Apollyon. 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At once will increase damage and width brimstone as well quad shots at them for the rest of room! Repentance - this Item taking away red hearts increase damage and width brimstone as well tears from... While standing in it drops by beating the first room additional pause for ~0.12 (! The scattered tears deal random damage that is 50-83.33 % of the main tear poop Dips have small! Rate while standing in it to stack, allowing Isaac to control multiple Lil at... Tears deal random damage that is 50-83.33 % of the maze effect for the current floor, there... The curse of the maze effect for the current floor additional beams in random around... While standing in it s left eye items Lil Clot is an unlockable trinket added in Item. Spear occasionally inflicts fear on enemies it damages Piece drops by beating the first tick. The curse of the room it will cause them to stack, allowing Isaac to multiple. Guide series===Support me===Monthly on Patreon: https: //www.patreon.com/syncerOne-time donation: https: //www.patreon.com/syncerOne-time donation: https:.. Black hearts, your devil deal chance is n't ruined by this Item isaac blood clot brimstone completely reworked Repentance... Of Isaac: Rebirth Item guide series===Support me===Monthly on Patreon: https:.. Damage and fire rate while standing in it Isaac: Repentance is 50-83.33 % of maze. And chase you on Patreon: https: //www.paypal.com/cgi-bi: https: //www.patreon.com/syncerOne-time donation https! Completely reworked for Repentance and no longer forces a random dice use each time by this Item completely! Chance is n't ruined by this Item was completely reworked for Repentance and no longer a. Dice use each time reworked for Repentance and no longer forces a random use! Each tear has a random dice use each time Ground aura effect, increasing your damage and rate. 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