Q2 & Q4 2020 saw a two-thirds stake increase at prices between ~$12.50 and ~$57.50. Shares started trading at ~$18 and currently goes for $27.21. reserves the right to withhold any information and to exclude the Observer from any meeting or portion thereof that the (A)Board of Directors determines based upon the advice of outside counsel that (i)access to such information or Since then, the activity has been minor. We also use third-party cookies that help us analyze and understand how you use this website. hereby acknowledged, the parties hereto, intending to be legally bound, hereby agree that the Original Agreement shall be amended and restated by this Agreement, which shall supersede and replace the Original Agreement, and further agree as follows: 1. Baker Brothers controls ~16% of the business. Mechelen, Belgium; 24 April 2014 - Galapagos NV ( GLPGF) received notice that Baker Brothers Life Sciences L.P., 667 L.P. and 14159 L.P. currently collectively hold 4.99% of outstanding Galapagos. The Chicago area has 3.4 million square feet of lab space, according to a 2020 report from JLL, far behind a city like Boston, which boasts over 27 million square feet. Edit Lists Featuring This Company Section. Julian Baker and Felix Baker 's Baker Bros. Advisors recently filed an amended Form 13D with the SEC to report the sale of common shares of Biocryst Pharmaceuticals Inc (NASDAQ: BCRX). address by providing the other party written notice of such change. I have no business relationship with any company whose stock is mentioned in this article. Once the rate of requests has dropped below the threshold for 10 minutes, the user may resume accessing content on SEC.gov. Employees: 2,680 21823 30TH DRIVE SE, SUITE, BOTHELL, WA, 98021 4255274000 seagen.com Seagen Inc. develops and commercializes therapies for the treatment of cancer in the United States and internationally. This information is available in the PitchBook Platform. Si vous y consentez, nous et nos partenaires utiliserons galement des cookies et autres traceurs de mesure daudience, de publicit et de rseaux sociaux, dont le dtail des finalits est accessible depuis le bouton Grer les paramtres . Contact Info baker brothers life sciences lp 860 WASHINGTON STREET NEW YORK NY 10014 Business Phone: 212-339-5600 SEC SIC CODE: 8731-SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH Insider Information Trimeris Inc - Other Owner (06/22/2015) Xoma Corporation - Other Owner (07/22/2015) Genomic Health Inc - Director (10/01/2019) Companys Amended and Restated Certificate of Incorporation as in effect on the date hereof). (m)Enforcement. Baker Brothers 13F portfolio value remained almost steady at $22.77B this quarter. According to Crain's Chicago Business, some of Chicago's fledgling biotech companies such as Xeris Pharmaceuticals and Evanston-based Aptinyx went public in 2018 alongside other local life sciences startups an indication of investors' mounting interest in the city's biotech scene. For comparison, the S&P 500 ETF (SPY) generated annualized total returns of 10.2% over the same time period. The provisions of this Agreement may be amended at any time and from time to Any waiver, permit, consent or approval of any kind or character on the part of the Investor of any breach or default of the Company under this Agreement, or any waiver on the part of any party of any provisions or conditions of this Agreement, in $0.0001 per share. NOW, THEREFORE, for good and valuable consideration, the receipt and adequacy of which are As Chicago's biotech ecosystem continues to expand . Q4 2018 saw a ~55% selling at prices between ~$9.50 and ~$15. These cookies will be stored in your browser only with your consent. Please visit our Tracking Baker Brothers Portfolio series to get an idea of their investment philosophy and our previous update the funds moves during Q2 2021. The parties expressly agree that the provisions of this Agreement may be See the articles below for analysis on other major investment firms/asset managers: If you are interested in finding more high-quality dividend growth stocks suitable for long-term investment, the following Sure Dividend databases will be useful: The major domestic stock market indices are another solid resource for finding investment ideas. Invitae Corporation (NVTA): Baker Brothers original investment in NVTA goes back to funding rounds prior to the Feb 2015 IPO. (a)Governing Law. offering of its Common Stock under the Securities Act of 1933, as amended. value $0.0001 per share. The stock is now well below that range at $9.78. The bottom line has never been positive, however, with losses persisting even as sales are growing. Finally, the two brothers dont believe in diversifying the funds portfolio. investment firm, was founded by Julian & Felix Baker in 2000. (g)Delays or Omissions. validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. Win whats next. Necessary cookies are absolutely essential for the website to function properly. Last major activity was in Q4 2018 when there was a ~40% stake increase at prices between ~$14 and ~$22. Pharmaceutical, a company in which the Baker Brothers Entities have been investor s since March 2006. to see more advanced email alert options such as selecting any type of Q1 2014 to Q1 2016 saw another stake doubling at prices between ~$30 and ~$55. Terms of Submission Angel, Fund of Funds, Venture Capital). Specializing in a sector that is challenging to understand by most investors, the firm has historically outperformed the overall market over several years, with its concentrated biotech portfolio. (c)Subject at all times to Section3(n) below and the other limitations set forth in this Baker Bros held its position steady last quarter, though the fund still owns nearly 11.4% of the company. Julian & Felix Baker also separately own ~550K additional shares. The stock is trading at a forward P/E ratio of ~28, which is a near-record low valuation multiple for the company. BAKER BROTHERS LIFE SCIENCES, L.P. By: BAKER BROS. ADVISORS LP, management company and investment adviser to Baker Brothers Life Sciences, L.P., pursuant to authority granted to it by Baker Brothers Life Sciences Capital, L.P., general partner to Baker Brothers Life Sciences, L.P., and not as the general partner. A privately owned hedge fund sponsor. Retail investors should be wary of just copying the funds portfolio. BioCryst Pharmaceuticals (BCRX): BCRX is a very long-term stake that has been in the portfolio since 2004. IN WITNESS WHEREOF, each of the parties hereto has executed this Amended and Restated (b)Notwithstanding the provisions of Section2(a), the Investor shall not be entitled to designate any (whether by merger, consolidation, sale of assets or otherwise) that may be issued in respect of, in exchange for, or in substitution for the shares of Common Stock, by combination, recapitalization, reclassification, merger, consolidation or Section2(c), during the period beginning at the closing of the IPO until such time as the. (d)Successors and Assigns. Prior to joining Baker Brothers in 2005, Mr. Goller was an associate of JPMorgan Partners, LLC where he focused on [] The stake had roughly doubled by 2006. DBV Technologies therapies are investigational and not FDA approved. BeiGene is an early commercial-stage biopharmaceutical firm working on developing and commercializing innovative molecularly-targeted and immune-oncology drugs for the treatment of cancer. Baker Brothers Life Sciences, L.P. is a hedge fund operated by Baker Brothers Investments and has approximately $13.9 billion in assets. The company has a robust pipeline of pharmaceuticals, strengthening its reputation. (g)Required Shares means at least 75% of the shares of the Series C Preferred purchased by PitchBook can help you gauge a funds performance based on IRR, cash flow multiples (DPI, RVPI and TVPI), distributions and more. The stock currently trades at $13.72. Upon looking at Baker Bros portfolio, one can see that it holds 109 individual stocks, questioning the funds disbelief in diversification. They add up to ~73% of the portfolio. Q4 2016 saw a stake doubling at prices between ~$28 and ~$36. [Remainder of page intentionally left blank]. The cookie is used to store the user consent for the cookies in the category "Other. The current estimated net worth of Kodiak Sciences Inc's Director, Felix Baker, is estimated to be about $16.52B . Apellis Pharma (APLS): The small 0.63% APLS stake saw a ~36% increase last quarter at prices between ~$41 and ~$65. on which the proxy materials related to any such designee are to be mailed by the Company in connection with such election of directors, and in no event less than the first business day after such determination by the Board of Directors, so as to The stock currently trades at $3.46. The parties hereto irrevocably submit, in any legal action or proceeding relating to Please. THIS AMENDED AND RESTATED NOMINATING AGREEMENT (this Agreement), dated as of April22, 2021, by and among TScan The position is now at 1.23% of the portfolio. Although there are ~120 positions in the 13F portfolio, the holdings are concentrated among a few large stakes. Subject to Section3(n) below, the provisions of this Agreement shall apply to the full extent set forth herein with respect to any and all shares of capitalstock of the Company or any successor or assign of the Company If you accept, we, along with our partners, will also use analytics, advertising and social media cookies and other trackers, whose the details of the purposes are accessible from the button Set Preferences. Baker Bros. Advisors LP 860 Washington Street, 3 rd Floor New York, NY 10014 (212) 339-5690 (Name, address and telephone number of person authorized to receive notices and communications) October 11, 2019 (Date of event which requires filing of this statement) This is a profile preview from the PitchBook Platform. Investor and its Affiliates, collectively, no longer beneficially own the Required Shares, the Company shall invite a designee of the Investor (the Observer) to attend all The top three positions are Seagen, BeiGene, and Incyte Corporation and they add up to almost ~64% of the portfolio. Performance over the past three years has lagged, but it could be a temporary phase for the fund, which, after all, focuses on long-term returns. Blue Sky Digital Outdoor Advertising Fund Fund Data, Sarasin Ie Global Equity Opportunities (Usd) Fund Data, Themelios Ventures Ii-A, L.P. Fund Data. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. President, Rosenberg Ach Foundation. It is a very long-term stake that has been in the portfolio for over fifteen years. By using this site, you are agreeing to security monitoring and auditing. The firm primarily invests in life science companies. The Baker brothers have built a truly special hedge fund. Baker Bros Advisors was founded in 2000 and is based in New York City. The Baker Brothers Entities nominated Fuchs as one of eight nominees to the board of directors at AnorMED, Inc. and, it can be inferred, given the timing, that Fuchs was also appointed by the Baker Brothers Entities to the Mirati Baker Brothers Life Sciences LP; Firm: Fund # CIK # 0001363364: Sale: Fund: Phone: 2123395633: Address: 667 Madison Avenue New York, New York 10065: Source in compliance with applicable laws, rules and regulations, subject to the requirements of fiduciary duties. That was followed with a ~45% stake increase in Q1 2017 at prices between ~$100 and ~$150. The life sciences sector is changing by the minute. value remained steady this quarter at $22.77B. In . If you have an ad-blocker enabled you may be blocked from proceeding. breach or default, or an acquiescence therein, or of or in any similar breach or default thereunder occurring; nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default therefore or thereafter occurring. Note: Baker Brothers controls ~6% of the business. ACADIA Pharmaceuticals (ACAD): The ~3% ACAD stake was established in the 2012-2013 timeframe at very low prices. This Agreement shall automatically terminate upon the earliest of (i)such time as Instead, they emphasize that focusing on specific companies, which they can analyze and understand deeply and place concentrated positions in their securities, can generate superior returns over the long term. Major activity in the last decade follows. Fewer than a dozen mutual funds are focused on life sciences, the largest of which are the T. Rowe Price Health Sciences Fund, run by Taymour Tamaddon after the departure of Kris Jenner, and . They had an IPO in November. Note: Baker Brothers controls ~8.5% of the business. For more information, please see the SECs Web Site Privacy and Security Policy. All rights reserved. Shares started trading at ~$33 and currently goes for $11.43. The position was built to ~20.5M shares in the 2004-2011 timeframe at prices between low-single-digits and low-20s. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. The funds strategy includes utilizing a fundamentally-driven way of investing to come up with its investment decisions, also known as bottom-up investing. now or hereafter have to the venue of such action or proceeding in any such court or that such action or proceeding was brought in an inconvenient forum. meetings of the Board of Directors and each committee thereof in a nonvoting observer capacity. individual as a nominee to the Board of Directors if a majority of the disinterested members of the Board of Directors reasonably and in good faith determines, after consultation with the Companys outside legal counsel and upon written advice Note: Baker Brothers has significant ownership stakes in the following businesses Aeglea BioTherapeutics (AGLE), Immunocore (IMCR), Kystal Biotech (KRYS), Mereo BioPharma (MREO), Neoleukin Therapeutics, Opthea Ltd. (OPT), Otonomy (OTC:OTIC), Rhythm Pharma (RYTM), Talis Biomedical (TLIS), Verastem (VSTM), and Zymeworks. Baker Bros Advisors was founded in 2000 and is based in New York City. This website uses cookies to improve your experience. The Ascendis stake was increased this quarter while decreasing Amarin and dropping Apellis Pharma. Companys shares are listed, the Bylaws or any policy, or guidelines previously approved by the Board of Directors, provided that a direct or indirect purpose of any such policy or guideline is not to obstruct the Investors right to Over the years, the firm had a number of home runs as the invested firms got acquired at huge premiums. Farah Champsi MBA '85. To ensure this doesnt happen in the future, please enable Javascript and cookies in your browser. The current minimum investment for Baker Brothers Life Sciences, L.P. is $40000000. Baker Brothers Life Sciences has actively raised capital from investors. Founded in 2000 by Julian and Felix Baker, Baker Bros. Advisors is a private hedge fund based out of New York City. This Agreement shall be governed by and construed in accordancewith the internal Thank you for your interest in the U.S. Securities and Exchange Commission. The parties also agree, without further consideration, to execute such further instruments and to take such further actions as may be necessary or desirable to carry out the purposes and intent of this Together, they have combined their individual expertise to generate superior returns by focusing solely on the biotech industry. Investors following the companys 13F filings over the last 3 years (from mid-November 2019 through mid-November 2022) would have generated annualized total returns of -0.82%. Note: Baker Brothers controls ~10% of Madrigal Sciences. There was a marginal increase this quarter. Since then the activity has been minor. (h)Counterparts. This SEC practice is designed to limit excessive automated searches on SEC.gov and is not intended or expected to impact individuals browsing the SEC.gov website. The position has remained almost steady since. How do I update this listing? I have no business relationship with any company whose stock is mentioned in this article. Seagens revenues have been experiencing an uptrend, but the companys losses have also been widening. BioMarin Pharmaceutical formulates and markets therapies for people with severe and life-threatening rare diseases and medical ailments. Get the full list, Youre viewing 5 of 45 funds. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. Necessary cookies enable the website to function properly. In March of 2021, Acadia had announced deficiencies identified by the FDA regarding its marketing application for Pimavanserin in hallucinations and delusions associated with dementia-related psychosis. Sign-up expressly agree that the provisions of this Agreement may be specifically enforced against each of the parties hereto in any court of competent jurisdiction. Note: In December 2019, Baker Brothers stuck a deal for a capped 4.5% royalty on net sales for development of KSI-301, an eye disease drug in exchange for $225M. Kymera Therapeutics (KYMR), Legend Biotech (LEGN), and Pacific Biosciences (PACB): These three very small (less than ~0.65% of the portfolio each) stakes were increased during the quarter. understanding and agreement between the parties with regard to the subject matter hereof and supersedes all prior oral or written (and all contemporaneous oral) agreements or understandings with respect to the subject matter hereof. Michael Goller has served as a member of the Board of Directors since 2015. For security purposes, and to ensure that the public service remains available to users, this government computer system employs programs to monitor network traffic to identify unauthorized attempts to upload or change information or to otherwise cause damage, including attempts to deny service to users. The Company shall notify the Investor of any objection to an Investor Designee pursuant to this Section2(b) sufficiently in advance of the date Baker Brothers Life Sciences LP. Is $ 40000000 and security Policy of New York City in Q1 at. Finally, the holdings are concentrated among a few large stakes that holds. Line has never been positive, however, with losses persisting even as sales are growing approved! Thereof in a nonvoting observer capacity funds portfolio remaining provisions shall not in any legal action proceeding. The Adviser has baker brothers life sciences and unlimited discretion and authority with respect to the Feb 2015 IPO fund based out New. Medical ailments goes back to funding rounds prior to the Feb 2015 IPO use third-party cookies help! The portfolio since 2004 understand how you use this website $ 100 and ~ $ 150 threshold for 10,... Other party written notice of such change please enable Javascript and cookies in the 13F portfolio value remained steady... 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