Timestamps: (00:24:33) AMP-activated protein kinase (AMPK) & Metformin In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. "David is a superb Information / Cyber-security executive in every respect. 2023 House / Tech / Progressive / Deep / Melodic / Techno / Edm / Afro / ibiza DJ Mix / Set / Podcast / Electronic Dance Music Radio Tomorrowland workout club 2022 party playlist beach tribal tiesto top What Causes Aging - and What Could Reverse It - with Dr. David Sinclair, Dr. Stephen Tates, Danyell Smith, Lynn Pinder & Pastor Yerby l The Carl Nelson Show, #340 The New Science of Awe & How It Improves Your Physical & Mental Wellbeing with Dr Dacher Keltner. Upcoming episodes will cover: why aging is a disease, the impact of dietary choices, fasting and exercise on aging, how various supplements and prescription drugs can protect against aging, why cosmetic aging occurs and how to combat it, the benefits and advancements of biotracking, and the future of age reversal. Our Patreon page: https://www.patreon.com/davidsinclair (01:03:50) Applying Heat The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. (01:03:06) Putting in the Work for Longevity (00:45:02) Resetting the Aging Clock (00:11:33) NAD Boosters Join us as host Shane Parrish uncovers the timeless lessons and insights you can use to get lasting results. For Longevity, NMN, NR, Resveratrol, Metformin & Other Molecules for Longevity. He is an expert and pioneer in the field of aging. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Welcome to the mind of David Sinclair, PhD , one of the world's leading scientific authorities on longevity, aging and how to slow its effects. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. In a paper published last month, the Harvard biologist David Sinclair reports that he and his co-authors have found the answer. Tex, CAUTION: This conversation contains themes of an adult nature and references to sexual assault. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclairOur Patreon page: https://www.patreon.com/davidsinclairLifespan book: https://amzn.to/3sUqurTDr. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. * Athletic Greens - https://athleticgreens.com/sinclair Unveiling the stories behind the very special people who have devoted their life to people. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser . (01:10:04) Next Week: Molecules & Supplements The expert technical and management leadership David continued to display resulted in an extremely high degree of . Dr. Sinclair has published groundbreaking (00:28:32) Homocysteine, Plaque, and Vasculature (00:13:24) Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) & Communicators (e.g., Insulin) With over 30 years of experience treating clients including A-listers and athletes, Marisa addresses common issues in a current context. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. A podcast about health, science, nutrition, aging, and fitness. Dr. Sinclair's book, Lifespan. (00:34:45) Autophagy and Retinoids (00:30:16) Cutting-edge Testing and Biological Age * InsideTracker - https://insidetracker.com/sinclair His podcast contains 9 episodes with the latest episode updated on February 23, 2022. Your partner being intimate with another guy should evolutionarily be one of the biggest fears of a man's life. (00:23:26) Plant-based Diets and B-vitamins Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclairOur Patreon page: https://www.patreon.com/davidsinclairLifespan book: https://amzn.to/3sUqurTDr. * Twitter Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker - https://insidetracker.com/sinclairOur Patreon page: https://www.patreon.com/davidsinclairTimestamps:(00:00:00) Introducing Episode 3: Exercise Hot Cold(00:01:01) A Pernicisous Element Called Iron(00:02:46) A Quick Primer on Free Radicals(00:05:42) Review of Dietary Takeaways(00:07:01) Sponsors(00:09:32 Biological Adversity & the Survival Circuit(00:13:24) Survival Sensors (i.e., mTOR, AMPK, and Sirtuins) & Communicators (e.g., Insulin)(00:17:25) Get Off Your Butt(00:19:40) Exercise Protects against Disease & Mortality(00:21:17) Daily Step Count and Walking After Eating(00:22:33) Exercise Activates AMPK and Creates More Mitochondria(00:24:03) Vigorous Exercise, Hypoxia, the Electron Transport Chain(00:28:19) Exercise Increases Glucose Sensitivity and Stimulates Blood Vessel Formation(00:32:13) The Epigenome and Biological Age are Impacted by Exercise(00:36:43) How to Measure your Biological Age(00:37:31) Exercise Recommendations(00:39:28) Wearables and Individualized Health Tracking(00:43:14) The Importance of Weight Training(00:46:08) Physical Activity & Senescent Cells(00:48:01) Wrap-up & Takeaways(00:49:47) Hyperbaric Oxygen Therapy(00:57:24) Cold Therapy(01:03:50) Applying Heat(01:07:04) Adversity Mimetics Produce Endorphins(01:08:07) A Basic Protocol for Mimicking Adversity(01:10:04) Next Week: Molecules & Supplements(01:10:45) Subscription & SupportFor the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. (00:49:10) Spermidine Taking pills isn't sufficient. (00:07:11) Acknowledgement of Sponsors (00:09:51) Thanking the Sponsors Will are testing other easier and faster parameters such as increase body functions - strength, walk speed, metabolism, heart health. This article has some show notes and a commentary on David Sinclair's new podcast (and a link to the video).. Journalist A. Peter Bailey, who was at the Audubon Ballroom the evening Malcolm was killed will be in our classroom. (00:28:15) Collagen, Keratin, and Skin Health Our Patreon page: https://www.patreon.com/davidsinclair It's a troubling site. Text "DCnews", CAUTION: This podcast contains swearing Our mindset is so important for living a happier, healthier life. * Levels - https://levels.link/sinclair * Twitter Thats one reason I felt like Gaia Bernsteins new book was talking directly to me. * Twitter Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. Lifespan book: https://amzn.to/3sUqurT Topics discussed include the science behind why we age and interventions for slowing and even reversing aging. Copyright 2023 Apple Inc. All rights reserved. * Twitter 9 episodes Join Dr. David Sinclair, Ph.D. in Lifespan, a popular health podcast that brings the cutting edge of aging and longevity science straight to you. (0:01:10) Sponsors (01:07:37) Todays Takeaways In this weeks episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. Before we hear from Dr. Tates, Black Women for Positive Changes', Danyell Smith kicks off Women's History Month. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan. Hear about the latest developments in aging. Recover your password They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. Top50 on Apple Podcast & Deezer ( Music Category ) in Spain Netherlands Russia Ukraine Bulgaria Hungary Romania & more Countries on the top 100 ( Source : itunes & Chartable.com ) Underground House Music DJ from Morocco LINKS: https://youtube.com/user/youness666b?sub_confirmation=1 https://podcasts.apple.com/fr/podcast/2021-house-tech-progressive-deep-defected-ibiza-uk/id1553828811 https://dj-tekness-morocco.business.site/ https://www.deezer.com/fr/show/2313652 @ DJ TEKNESS on Youtube Dee Dr. David Wensel interviews various guests who serve within the Medical Industry, Continuum of Care Industry, and Hospice Care Industry. Episode 6: The Science Of Looking Younger | Lifespan With Dr. David Sinclair. (00:53:20) Sleep Lifespan with Dr. David Sinclair is a new podcast from world renowned aging research doctor, David Sinclair, Ph.D. Dr. Sinclair is a professor of genetics and co-director of Harvard Medical School's Center for Biology of Aging Research. The health entrepreneurship podcast focusing on big picture stuff. * InsideTracker - https://insidetracker.com/sinclair Harnessing this knowledge, he was able to reverse this process, making mice younger, according to the study published in the journal Cell. In 2022 Ashley put together an international team to investigate the mysterious origins of a 400 year old light phenomenon in rural Colombia. Is it about happiness, health, friendship, love, or meaning? They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David Sinclair's Post David Sinclair Experienced In-house Counsel, Polar Expedition Leader/Guide, Nature Photographer, Founder and Director - Islands and Ice Travel 2w Edited Report this post . * Athletic Greens - https://athleticgreens.com/sinclair (00:51:35) Resetting the Aging Clock (00:30:57) Sirtuin Proteins as Epigenetic Regulators of Aging Author, Lifespan book & podcast. Select a membership level. (00:23:19) Cellular Senescence, Ultraviolet Light, and Skin Aging (00:29:22) NAD Intravenous Drips (00:09:22) The Brain Ages Slowly In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. (00:05:42) Review of Dietary Takeaways Joe Rogan Experience : aging, epigenome, genetics, healthspan, longevity, metformin, mtor, nad, nmn, rapamycin, resveratrol, sirtuin. (00:24:03) Vigorous Exercise, Hypoxia, the Electron Transport Chain (00:57:59) Aging is a Medical Condition * Athletic Greens - https://athleticgreens.com/sinclair Like the more you try to manage it, the more out of control it becomes? (00:09:54) Longevity Molecules Target the Survival Circuit (00:55:19) Frickin Laser Beams: Low-level Laser Therapy You're not supposed to just get older, you're supposed to mature as well. Its free, its easy, it doesnt require much of your time and the results can be instantaneous. Thank you to our sponsors: (00:12:57) The Pinch Test, Epidermal Thinning, and Foot Ulcers What does it mean to live a good life? (00:16:42) Organisms with Extreme Longevity (00:43:14) The Importance of Weight Training (00:02:39) Expressing Gratitude to the Sponsors Sirtuins. (01:04:56) Thanking the Podcast Team and Wrapping Up Season One Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. David Sinclair Podcast He serves as the host of Lifespan on Scicomm Media. (00:46:08) Physical Activity & Senescent Cells (00:53:45) Repeatable Age Reversal and Safety (00:50:33) Increasing Blood Flor Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. (01:09:25) Subscription and Support Options * Facebook For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. The Science of Looking Younger, Longer | Episode 6. (0:04:36) A Starting Place for Longevity: Eat Less Often These are the questions and topics we explore every week in conversation with leading voices from health, science, art, industry, mindset, and culture, like Bren Brown, Matthew McConaughey, Mel Robbins, Alex, Elle, Adam Grant, Elizabeth Gilbert, Yung Pueblo, Maya Shankar, Mitch Al Health Theory is a twice weekly interview show, hosted by Quest Nutrition co-founder, Tom Bilyeu. 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